{"id":99,"date":"2023-06-12T04:03:48","date_gmt":"2023-06-12T04:03:48","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-en\/?post_type=research-groups&#038;p=99"},"modified":"2026-04-20T09:44:53","modified_gmt":"2026-04-20T07:44:53","slug":"research","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"e6fcd6db-22e3-45ce-8525-4f10521b97c6\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Research \" type=\"button\">\n            <span class=\"btn__name mr-auto\">Research <\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/research\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link isactived\" aria-current=\"page\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research <\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/publications\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/people\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/ai-modelling-prediction\/join-us\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Join us<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"predictive-models\"\n    >\nPredictive models<\/h1>\n\n\n<figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/LCSB_Systems-Control_research.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/LCSB_Systems-Control_research-300x189.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/LCSB_Systems-Control_research-768x484.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/LCSB_Systems-Control_research.jpg 825w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: contain; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><span style=\"font-size: revert;background-color: var(--color-white);color: var(--color-gray)\">The group develops computational methods that extract information from with a wide range of time-series data. While time-series data is more expensive to produce than steady-state data, tracing a system\u2019s transient behaviour provides essential information on how different species interact with each other and reveals causal mechanisms.<\/span> <\/p>\n\n\n\n<p>Bringing together diverse backgrounds in mathematics and computational sciences, our group engages with this overall problem from different perspectives. Current initiatives include developing methods for inferring causality in gene regulatory networks from both average and single cell data, and pinpointing the source of diseases in these networks.  <\/p>\n\n\n\n<p>The models are subsequently validated experimentally, ensuring that our research has broad-ranging applications in biomedicine, including neurodegenerative diseases, cardiovascular diseases, mechanisms of circadian rhythms and stem cell differentiation.<\/p>\n<\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research-projects\"\n    >\nOur research projects<\/h2>\n\n\n\n<p>The AI Modelling and Prediction group is involved in several research projects focusing on algorithm development and data analaysis from time-series data:<\/p>\n\n\n\n<div class=\"wp-block-unilux-blocks-accordion accordion accordion--theme accordion-standard\" data-reference=\"9c6d1877-9dec-4d25-ac3b-59f84d29031d\" data-accordion-type=\"standard\"><div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-29b4329b-f9e4-41f9-b8b0-e6c6a18d6fe9\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-29b4329b-f9e4-41f9-b8b0-e6c6a18d6fe9\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-29b4329b-f9e4-41f9-b8b0-e6c6a18d6fe9\"\n        >\n            <span class=\"accordion__title\">\n                                Real-time prediction of heart attacks and arrhythmias            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-29b4329b-f9e4-41f9-b8b0-e6c6a18d6fe9\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-29b4329b-f9e4-41f9-b8b0-e6c6a18d6fe9\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Luxembourg National Research Fund (FNR)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>collaboration with partners in China and Argentina<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The aim of this project is to detect and predict heart arrhythmias before they occur. Heart attacks and arrhythmias typically happen without noticeable warning. Predicting heart arrhythmias, such as atrial fibrillation (AF), in real-time and with enough anticipation can allow patients to seek immediate medical attention and prevent health complications. This project searches for subtle changes in heart dynamics, captured via ECG or PPG (via a smartwatch, for example), using state-of-the-art machine learning tools.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-9679a174-35a9-4b7b-8fef-6c02ee55f339\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-9679a174-35a9-4b7b-8fef-6c02ee55f339\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-9679a174-35a9-4b7b-8fef-6c02ee55f339\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Network inference<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-9679a174-35a9-4b7b-8fef-6c02ee55f339\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-9679a174-35a9-4b7b-8fef-6c02ee55f339\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Luxembourg National Research Fund (FNR)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Department of Plant Sciences at the 8xav福利导航 of Cambridge and the Institute of Biology Leiden<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The aim of these projects is to understand how networks of genes and other molecules causally interact over time to produce disease related phenotypic behaviours. Reliable models of these regulatory networks allow us to simulate hypotheses that can be used to guide experimental testing, and to identify changes in biological network structures that occur when a system is perturbed in responses to stimulation, pharmacological intervention or genetic mutations. Networks are inferred from time-series or single-cell data. The project contributes to broad theoretical research into mathematical, algorithmic and software tools to help understand causal dynamic network structures and interactions between different omics layers, such as metabolomics and transcriptomics. The developed tools are applied to understand the mechanisms of action of several organisms and time scales such as circadian clocks and the immune system.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-792c5fd5-34c0-4bdb-98a7-8bdb2c222336\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-792c5fd5-34c0-4bdb-98a7-8bdb2c222336\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-792c5fd5-34c0-4bdb-98a7-8bdb2c222336\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Next generation of deep brain stimulation (DBS)<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-792c5fd5-34c0-4bdb-98a7-8bdb2c222336\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-792c5fd5-34c0-4bdb-98a7-8bdb2c222336\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Luxembourg National Research Fund (FNR) and JPND Research Joint EU Programme<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Centre Hospitalier de Luxembourg (CHL), the 8xav福利导航 of Oxford, and partners from the Netherlands, Germany and Sweden.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Deep Brain Stimulation (DBS) is a surgical therapy for several movement disorders (e.g. Parkinson\u2019s disease (PD) and essential tremor) and psychiatric diseases. During this procedure, an electrode is implanted into the brain, constantly delivering electrical pulses to specific regions of the brain. This project aims to considerably improve the efficiency of DBS while reducing side effects. In particular, it develops algorithms to deliver personalised stimulations that adapt to the patient\u2019s needs, and computational tools to aid physicians initialize DBS parameters.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-de277dad-1608-457d-9d9c-0bd8d95b0428\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-de277dad-1608-457d-9d9c-0bd8d95b0428\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-de277dad-1608-457d-9d9c-0bd8d95b0428\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Critical transitions<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-de277dad-1608-457d-9d9c-0bd8d95b0428\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-de277dad-1608-457d-9d9c-0bd8d95b0428\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Luxembourg National Research Fund (FNR)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Catastrophic events (i.e. sudden changes that affect systems stability) occur in various fields and at various levels. Examples include earthquakes, stock market crashes and population extinction. It is hypothesised that the onset of diseases such as cancer follows similar patterns. If we could understand the critical transitions (CTs) that induce catastrophes, we would be better equipped to prevent them arising or at least to mitigate their effects. The proposed research confronts this problem within a range of disciplines in the areas of clinical science, immunology, biology and finance. It aims to classify CTs according to their general dynamical features and then to provide the foundations for:<\/p>\n\n<p>a)Identifying early warning signals to enable more timely, reliable predictions of catastrophes.<br>b)Developing tools to model, analyse, and detect CTs in diverse areas of application.<\/p>\n\n<p>Ultimately, the overall goal of the project is two-fold: to support more advanced research on CTs within different scientific disciplines and to improve society\u2019s ability to anticipate critical transitions to undesirable states in multiple fields<\/p>\n\n<p>The project entails eleven doctoral students and ten supervisors.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-ed79258f-3ed0-49a3-bd9f-f6589ccd1421\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-ed79258f-3ed0-49a3-bd9f-f6589ccd1421\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-ed79258f-3ed0-49a3-bd9f-f6589ccd1421\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Predicting financial crashes<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-ed79258f-3ed0-49a3-bd9f-f6589ccd1421\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-ed79258f-3ed0-49a3-bd9f-f6589ccd1421\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Luxembourg National Research Fund (FNR)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>collaboration with the Luxembourg School of Finance<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The project aims to study hidden statistical patterns in financial systems to test potential early warning signals for critical transitions in equity markets. Financial markets are known for their complexity due to the presence of many different types of agents whose actions belong to a very diverse set of strategies. This project studies the causal effect of latency delays on occurrence of mini-flash crashes. This latency delay slows down the trading while reducing price impact, and results in decreased number of mini-flash crashes.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-8d9c6ecf-903f-4a47-a7d0-2cd150fc28c2\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-8d9c6ecf-903f-4a47-a7d0-2cd150fc28c2\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-8d9c6ecf-903f-4a47-a7d0-2cd150fc28c2\"\n        >\n            <span class=\"accordion__title\">\n                                <strong><strong>COVID-19 dynamical modelling<\/strong><\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-8d9c6ecf-903f-4a47-a7d0-2cd150fc28c2\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-8d9c6ecf-903f-4a47-a7d0-2cd150fc28c2\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>2020-2023<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The spreading of the COVID-19 pandemic within a community changes over time. Since March 2020, our dynamical models have been assessing its severity, anticipating future evolutions and providing information to aid the Luxembourgish Government in decision making. We explored a range of models, from simple epidemiological models to detailed individual agent-based models to simulate the effects of different confinement and deconfinement measures and vaccination policies, among others. Models included forecasts of hospital, ICU and deaths and the impact on the local economy. A quantitative model estimated the infected population from viral samples collected in wastewater, providing an alternative for an efficient and robust epidemic tracking. Finally, using critical transitions methodologies, we developed models to anticipate new waves of infections.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-1fb45b73-d77d-4386-80b0-183b92879ea9\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-1fb45b73-d77d-4386-80b0-183b92879ea9\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-1fb45b73-d77d-4386-80b0-183b92879ea9\"\n        >\n            <span class=\"accordion__title\">\n                                <span role=\"textbox\" aria-label=\"Accordion Item Header\" class=\"block-editor-rich-text__editable rich-text\"><h3 class=\"accordion__header\"><span class=\"accordion__title\"><span role=\"textbox\" aria-label=\"Accordion Item Header\" class=\"block-editor-rich-text__editable rich-text\" style=\"min-width: 1px\">Morphogenesis: The topology and geometry of living systems<\/span><\/span><\/h3><\/span>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-1fb45b73-d77d-4386-80b0-183b92879ea9\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-1fb45b73-d77d-4386-80b0-183b92879ea9\"\n        data-bs-parent=\"[data-reference=&quot;9c6d1877-9dec-4d25-ac3b-59f84d29031d&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>2022-<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Jes\u00fas Fuentes, Maria Moscard\u00f3 Garcia<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Morphogenesis \u2013 the process that governs the formation and development of biological shapes and structures \u2013 is a central topic in developmental biology. Traditional models in this area often have limitations; for example, they might not adequately capture the dynamic interactions between cells or the influence of underlying tissue structures.<\/p>\n\n<p>Our research framework addresses these challenges by offering a more integrated approach. It accounts for both mechanical and geometric forces, as well as stochastic events and cellular activities like cell division and death. By considering these factors, our models can simulate interactions between cells in a way that reflects the inherent complexity and variability found in actual biological systems.<\/p>\n\n<p>Recently, we have introduced a model that incorporates data from both synthetic models and actual biological samples. This makes it a valuable tool for a wide range of applications: from understanding normal physiological development to exploring pathological scenarios. Our future work involves the application of these models for hypothesis generation in therapeutic research, particularly in examining complex tissue structures.<\/p>\n<figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"Morphogenetic Simulations of Synthetic Foil-Knot Structures.jpg\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-scaled.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-275x300.jpg 275w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-940x1024.jpg 940w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-768x836.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-1410x1536.jpg 1410w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Morphogenetic-Simulations-of-Synthetic-Foil-Knot-Structures-1880x2048.jpg 1880w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: contain; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 3\/2; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n<p><em>Figure<\/em>: Morphogenetic Simulations of Synthetic Foil-Knot Structures<\/p>\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Panel a: Originating from an initial configuration of 100 hypothetical cells arranged spherically, the model drives the cells to a foil-knot structure characterised by a single twist.<\/li>\n\n\n\n<li class=\"ulux-list-item\">Panel b: By extending the symmetrical properties inherent in the structure from Panel a, the model produces a two-foil-knot configuration, thereby demonstrating its capacity to adapt to enhanced topological complexity.<\/li>\n\n\n\n<li class=\"ulux-list-item\">Panel c: Upon distorting the initial foil-knot configuration and inducing cellular division up to a final cell count of 450, the model maintains stability, contingent on the uniformity of cell-to-cell adhesion.<\/li>\n\n\n\n<li class=\"ulux-list-item\">Panel d: This panel illustrates the destabilisation that occurs in the tissue configuration from Panel c when the elastic properties of the cellular ensemble are varied.<\/li>\n<\/ul>\n<div class=\"thumbnail  wp-block-unilux-blocks-thumbnail-video\">\n    <div class=\"card bg-theme p-0\">\n        <div class=\"card__container p-0\">\n            <div class=\"card__body p-0\">\n                <iframe \n            src=\"\" \n            title=\"YouTube video player\" frameborder=\"0\" \n            allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" \n            style=\"object-position: 50% 50%; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n            allowfullscreen data-cookieconsent=\"ignore\">\n            <\/iframe>                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n<p>Dynamic Simulation of Foil-Knot Morphogenesis: This video captures the simulated evolution of a structure analogous to that depicted in Panel b of the figure. Commencing from a spherical spatial distribution, the cellular ensemble undergoes transformation to form a hypothetical foil-knot tissue.<\/p>\n\n<p>\u2757\ufe0fExperience from your mobile device a <a href=\"https:\/\/fuentesigma.github.io\/pygen\/\" target=\"_blank\" rel=\"noreferrer noopener\">3D morphology generated by PyGen in your own space using AR technology<\/a>. Simply tap the AR icon to start.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div><\/div>\n<\/div><\/section>\n\n\n<section class=\"section section wp-block-unilux-blocks-quick-link-discover-section\">\n    <div class=\"container xl:max-w-screen-xl\">\n        \n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"discover-more\"\n    >\nDiscover more<\/h2>\n\n<ul class=\"wp-block-unilux-blocks-quick-link-discover quick-link-list\">\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/research\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Research at the LCSB                 <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/join-us\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Join us                 <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/contact\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Contact us                <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n<\/ul>\n    <\/div>\n<\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":39,"featured_media":0,"parent":102,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"AI Modelling and Prediction","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[281,290,291],"organisation":[],"authorship":[39],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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